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Future research should also address whether CSE-induced downregulation of glycolytic flux is caused by disruption of the transcriptional activity of HIF-1 or by a recently reported mechanism by which HIF-1 is involved in the cytoplasmic formation of a metabolic complex involving several glycolytic enzymes [63]

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This can make them appealing for users who want to sidestep the mess and odor of traditional chewing tobacco

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But we need to go further, said Amy Lukowski, a psychologist at National Jewish Health and clinical director of its telephonic counseling to help people quit smoking