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Because they have fewer side effects and are more selective for malignant cells, targeted chemotherapeutical drugs are preferable to standard ones (187)

doi: 10.1074/jbc.273.33.20737 31 LiYZhangCChenXYuJWangYYangYet al

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Furthermore, melatonin combined with a ketogenic diet overcomes drug resistance to cisplatin and vincristine in BC-bearing mice by inducing apoptosis, inhibiting angiogenesis, lowering blood glucose, increasing ketone bodies, and downregulating resistance genes, achieving cure rates up to 70% 168