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Since NRF2 activation induces the antioxidant and detoxifying response to restore redox homeostasis state, in recent years there has been a growing interest in identifying and evaluating new compounds capable of targeting the KEAP1-NRF2 system, to induce cytoprotective response against OS

These AA/AdA-CoA derivatives are then synthesized with PE in the cell membrane by LPCAT3, producing AA/AdA-PE (Doll and Conrad, 2017)

Subcutaneous and intramuscular injections offer similar bioavailability

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