Use R53.1 when the record documents generalized weakness as a constitutional symptom without objective muscle weakness findings, or when the note supports debility/asthenia more than strength loss
Red flags requiring medical evaluation include progressive weakness, bowel or bladder dysfunction, unexplained weight loss, fever, or worsening symptoms despite treatment
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To date, there are no scientific studies that support this claim suggesting that further research in this area may be warranted
The association between vitamin B12, albuminuria and reduced kidney function: an observational cohort study