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Finally, our study has important clinical and therapeutic implications, both related to the design of new multitargeted therapeutic strategies based on the use of cortistatin for treating chronic neuropathic pain of different etiologies, and to the identification of cortistatin as a potential risk factor for developing severe neuropathic pain

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The transdermal composition of any of the preceding claims wherein penetration enhancer is one or more of Caprylocaproyl polyoxyl-8 glycerides, diethylene glycol monoethyl ether, and Isopropyl myristate