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Because alcohol and crack are central nervous system depressants, mixing the two substances can lead to the following dangerous side effects: Suicidal thoughts Coma Sudden death from overdose Imparied judgment and decision-making Risky behaviors like unprotected sex or driving under the influence When someone combines crack and alcohol, its classified as polydrug use, which is considered a more severe form of substance use that is accompanied by greater risks and a more complicated recovery process