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Are ferroptosis inducers effective in killing tumor cells in clinical therapy

Journal of Pineal Research, 34(4), 257-262

305 At the therapeutic level, therapeutic vaccines targeting Arg 1 have been shown to activate antitumor immunity in a variety of syngeneic mouse tumor models such as lung cancer, melanoma, and colon cancer, and the combination of Arg 1 vaccine with anti-PD-1 antibody can increase T cell infiltration, inhibit myeloid cell function, and increase the ratio of tumor-infiltrating M1/M2 macrophages

Animal studies confirm the peptide crosses the placental barrier and modulates growth factors active during embryonic development, but no reproductive toxicity studies have evaluated teratogenic risk

This association may be attributed to low levels of histone H4 acetylation at the Nrf2 gene promoter, leading to Nrf2 transcriptional inactivation [139,140]