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The inner and outer box sizes were set as 10 and 25 respectively (except 30 for the outer box of C23)

3 Endogenous substances and life span extension 3.1 Alpha-ketoglutarate and Oxaloacetic acid -Ketoglutarate ( 24 , 2-oxypentanedioic acid or 2-oxy-glutaric acid) is present in all organisms and is an important small molecule metabolite in cells

2009;4(5) doi: 10.1371/journal.pone.0005515.e5515 [DOI] [PMC free article] [PubMed] [Google Scholar] 64.Cuervo AM, Stafanis L, Fredenburg R, Lansbury PT, Jr., Sulzer D

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Fecal microbiota transplantation significantly improved respiratory failure of amyotrophic lateral sclerosis