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US Food and Drug Administration 2012, 696 F.3d 1205, 1214 (DC Cir 2012))

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According to the American Heart Association, nicotine use can potentially cause an increase in: Blood pressure Heart rate Flow of blood to the heart Narrowing of the arteries, or vessels that carry blood On top of that, nicotine use can cause the hardening of the arterial walls, which in turn, may lead to a heart attack