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From this shared extracellular microenvironment, GSH is cleaved by -glutamyl transpeptidase on the astrocytic plasma membrane to generate precursors for neuronal GSH synthesis

It is limited to a maximum of 5 days and carries standard NSAID risks including GI and renal effects

Genomic epidemiology methods further suggest a potential link between the increasing clinical incidence of azole-resistant IA and the increasingly widespread presence of azole-resistant genotypes in environmental isolates ( 3 Common antifungal drugs and associated resistance mechanisms Common antifungal drugs include polyenes, azoles, allylamines, morpholines, and echinocandins, all of which function as antimetabolic agents targeting essential fungal structures or biosynthetic pathways (Fisher et al., 2022

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