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However, in tauopathies such as AD, as well as in hibernation, tau undergoes hyperphosphorylation catalyzed by various protein kinases, including but not limited to glycogen GSK3, cyclin-dependent kinase 5 (CDK5), and protein kinase A (PKA) [103,104,105], accumulating an excess of 7-10 phosphate groups [106]

Rat Reactive Oxygen Species (ROS) Enzyme-Linked Immunosorbent Assay (ELISA) Kit was purchased from King Biotech Life Sciences (Mukund Nagar, India)

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A kinase anchor protein 4 is vulnerable to oxidative adduction in male germ cells