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Conversely, the lactone form can be converted into the hydroxy-acid form by hydrolysis mediated by carboxylesterases, specifically by hCE1, found in the cytoplasm and endoplasmic reticulum of hepatocytes in the liver (Casey Laizure et al., 2013

& Rasheed, Z

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Burda, K., Czarnecka, K., opaciska, O., Staczyk, K., Korn, A., Wjcik, E., Korczak, A., Jdrzejczyk, J., Szewczyk, O., & Olek, E

For 8 weeks, all drugs were given by oral gavage and behavior assessments were conducted one day after the last dose administration