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Similarly, patients with bleeding disorders or those at high risk for bleeding complications may require careful evaluation before initiating peptide therapy

(2006) Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2

Ledowsky C, Steel A, Schloss J

This is due to the hydrophobic nature of isoleucine and alanine, which leads to a less soluble peptide that adopts an equilibrium of monomers, trimers and tetramers, whereas A 140 is mostly monomeric (Chang and Chen, 2014)