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doi: 10.1046/j.1365-2265.1998.00441.x

Research shows that both moderate-intensity continuous training (MICT, 50%70% VO 2 max) and high-intensity interval training (HIIT, 85%95% VO 2 max) can effectively activate the Nrf2 pathway, with HIIT being 30%40% more effective in upregulating antioxidant enzymes than MICT (Martinez-Canton et al., 2024)

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The subsections that follow discuss zinc, vitamin A, and pyridoxine, which are often used to treat symptoms other than delayed cognition in DS

Surprisingly, we still detected an induction effect of DMF on most of the factors studied despite NRF2 silencing (Fig