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In 2004, aromatase inhibitory activity of SB in leiomyoma cells was reported and the enzyme was inhibited in a time- and dose-dependent manner (Lee et al., 2004b)

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Notably, there was a significant upregulation in the mRNA expression of immune-related genes, including TLR1 , TLR2 , TLR3 , TLR4 , TLR5 , TLR7 , TLR15 , MHC I , MHC II , and MyD88 at various time intervals

Okay, well, that's kind of merging into two different arenas

Exosomes mitigate POF by exerting anti-apoptotic activities, such as exosomal miR-21-5p inhibiting PTEN and caspase-3, hence decreasing GC apoptosis