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These agents offer more targeted approaches than traditional immunosuppressants, but they still involve significant immune suppression and come with substantial costs and potential side effects

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There is slower migration of fibroblasts and wound-healing cells to these sites of injury owing to the poor blood supply, and therefore the repair process is obstructed

Suzuki A, Xiao L, Taketa T, Sudo K, Blum MA, Komaki R, Liao ZX, Lee JH, Bhutani MS, Weston B, Hofstetter WL, Swisher S