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Whilst palpitations during a calorie deficit are often benign and self-limiting, they should not be dismissed without proper assessment, particularly if they are frequent, prolonged, or accompanied by other symptoms

Nevertheless, future research should focus on examining temporal relationships between HPA axis function and immune-inflammatory or nitrosative stress pathways through biomarkers like TNF-, IL-10, TGF-, inducible NO synthase, NO production, protein nitrosylation, and bacterial translocation in ME/CFS patients to better understand their roles [79]

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"Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications"