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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

Dez, J

Harnessing a novel liposome-based assay developed by postdoctoral researcher Shanshan Liu and Ph.D

J Pharmacol Sci 113:378386 Tsai G, Lane H-Y, Yang P, Chong M-Y, Lange N (2004) Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia

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