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In the lung, paracellular permeability is increased through p38 mitogen-activated protein kinases, Mylk3 (also known as MLC kinase) phosphorylation, and Rac1 (Schweitzer et al., 2015)
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Consequently, when e-cigarettes are used as a complete alternative to combustible cigarettes, they may reduce the risk of certain smoking-related diseases, including lung cancer and cardiovascular disease
Once further validated across other contexts, the HEIC is a potentially useful tool for clinicians, policy makers, and communities, which could help whnau (extended family, family group), schools, communities, clinicians and policy makers to better understand the health-relevant features of environments that children live in
However, symptoms of the condition may not appear for another 20 to 30 years
