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Pathologists will analyze these biopsies in order to diagnose the condition and determine the presence and degree of dysplasia, which is used to grade an individuals risk of progression to cancer

However, clinical application of these enzymes is usually hindered by common problems including allergy to these foreign proteins, off-target cytotoxicity, short half-life and rapidly emerging chemoresistance

Francis AM, Sepesi B, Correa A, Mehran R, Rice DC , Roth JA, Vaporciyan AA, Walsh GL, Welsh J, Swisher SG, Hofstetter WL

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This is particularly useful for longterm hostadapted strains of , such as those persisting in the CF lung, which typically develop a multidrugresistant profile as the result of repeated antibiotic therapies