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Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist

Kravitz AV, Freeze BS, Parker PR, Kay K, Thwin MT, Deisseroth K, et al

There is also recent data which suggest that genetic alterations of the receptor by which B12 is transported into nerve tissue and the brain, may lead to a lower B12 uptake

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And so, this brings back our question: How long does a B12 shot last and stay in your system