New York, NY: Informa Healthcare
Di Paola R, Modafferi S, Siracusa R, Cordaro M, D'Amico R, Ontario ML, Interdonato L, Salinaro AT, Fusco R, Impellizzeri D, Calabrese V, Cuzzocrea S
The formation of 8-OHdG, a modified nucleoside, is a consequence of oxidative DNA damage, particularly guanine residues (181)
2023 [cited 2023 Sep 5];7:e70617
Research employing PET tracers targeting the mitochondrial translocator protein (TSPO), such as [ 8 F]DPA-714, has demonstrated that some PCC patients continue to exhibit widespread elevated TSPO signals in the brain up to two years post-infection, with the intensity of this increase being most pronounced in individuals with persistent fatigue and cognitive symptoms (147) Animal studies have further substantiated that the sustained elevation of TSPO-PET signals (lasting at least 50 days) following SARS-CoV-2 infection arises from the co-activation of microglia, astrocytes, and endothelial cells, and that this neuroinflammatory state can endure long after viral clearance in the peripheral tissues (154)
