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However, the manufacturing process itself requires careful control, such as multi-step syntheses, purification through distillation, and enantiomeric purity checks to ensure the final product is pure S-nicotine, the same form naturally found in tobacco plants

Oh well, I enjoyed it all back then.

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

This system evolved over millions of years

Numerous effective medications are available for tobacco dependence, and clinicians should encourage their use by all patients attempting to quit smokingexcept when medically contraindicated or with specific populations for which there is insufficient evidence of effectiveness (i.e., pregnant women, smokeless tobacco users, light smokers, and adolescents)