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In the acute phase, symptoms include euphoria, anxiety, paranoia, and psychomotor agitation, which are primarily caused by the short-term overactivation of neurotransmitter systems ( 2.3.1 Cognitive impairment METH abuse significantly impairs cognitive function by targeting key brain regions ( 2.3.2 Psychiatric symptoms METH abuse disrupts the functionality of various brain regions, including the prefrontal cortex, nucleus accumbens, and thalamus, leading to significant psychiatric disturbances (Sekine et al., 2001)

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Ipamorelin could thus represent an effective and cheaper alternative to the current options for the treatment of bone loss, such as bisphosphonates, hormonal treatment with PTH or new monoclonal antibodies

C., MeloOliveira, R