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They can have an opposite effect (most commonly) or parallel effect (note, this parallelism occurs with quite distinctive models, i.e., amphetamine-effect [70], miosis [91], atropine-mydriasis [91], huge magnesium over-dose [85], ischemic/reperfusion colitis [49], duodenal congestion lesions [251], cecum perforation [174])

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It is well-tolerated in animal and early clinical studies, even at multi-milligram doses [12]

What the Evidence Actually Shows Being transparent about the evidence tier matters here more than for almost any other peptide, because the hype has outrun the approval timeline