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In some embodiments, the otic formulation or composition comprises between about 0.10% to about 10% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

This region-specific action is associated with its local stimulation of hormone-sensitive lipase and enhanced fatty acid oxidation, suggesting potential for site-selective metabolic modulation without systemic hormonal changes

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Mitochondria play essential roles in intracellular protection against oxidative stress-which molecules among the ROS generated in the mitochondria can escape the mitochondria and contribute to signal activation in cytosol

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