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Author contribution LE - developed the method, designed the study, performed measurements, analyzed the data, wrote the article

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GSH is mainly formed in the cytosol, however, GSSG is transported out of cells particularly when elevated possibly to maintain the high GSH/GSSG ratio although GSH is also transported out of liver cells possibly as a source of cysteine for other cells ( FIGURE 3 Induction of Changes in Intracellular ROS and Function in Response to Physiological Variations in Extracellular Redox Couples A redox communication system that shares information among metabolically sensitive tissues predicts that physiologically relevant changes in the putative redox indicator ratios will impact tissue ROS production and function

An update on the therapeutic role of alkylglycerols