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A way to explain cell death associated with reduced levels of GSH is ferroptosis, a unique iron-dependent form of non-apoptotic cell death, characterized by lipid peroxidation with ROS accumulation due to GSH peroxidase inactivation and high levels of GSH consumption

GSTs are involved in the main detoxification route of AFB1- exo -8,9-epoxide by catalyzing the conjugation of AFB1- exo -8,9-epoxide to endogenous GSH

NAC, on the other hand, is best known as a precursor to glutathione , meaning it helps your body produce more of this vital molecule

Cribb AE, Leeder JS, Spielberg SP

Differentiating Changes in Glutathione Levels from Cytotoxic Events Using Multiplexed Assays Alisha Truman and Brad Hook Promega Corporation Publication Date: October 2013 Abstract Measuring changes in glutathione levels as a single endpoint may not be sufficiently informative to differentiate a decrease in GSH from a cytotoxic event