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Although the optimal sleep duration for adolescents is about 9 hours each night (Carskadon et al., 2004), the average high schooler (14- to 18-year-olds) gets between 6 and 8 hours of sleep each night, largely due to early school start times and wake-inducing activities (e.g., social and academic activities) that interfere with sleep

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However, AEs could still occur more than a year after treatment initiation ( n = 429, 4.8%)

In (B) and (C) , data were analyzed with an ordinary two-way ANOVA with Tukeys multiple comparison test