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GSH is synthesized from three amino acids in two ATP-dependent enzymatic steps

Antioxidants are essential for the body to prevent oxidative damage

However, the expression of GPx1 has been reported to be down-regulated in thyroid cancer [44], colorectal cancer [45, 46], and gastric cancer [47], whereas GPx1 has been demonstrated to play an oncogenic role in kidney cancer [48], pancreatic cancer [49], and laryngeal squamous cell carcinoma [50]

While the clinical research surrounding N-Acetyl-L-Cysteine is highly encouraging, it is important to maintain a realistic outlook

Against this background, our patient had malignancy, prior ICI exposure, severe postoperative pneumonia, and concomitant use of several drugs with potential hepatic and/or cutaneous toxicityconstituting a typical susceptible host plus high-risk drug exposure profile and placing him at dual high risk for both DILI and SJS/TEN