It can be concluded that the dopaminergic deficit is efficiently compensated for a long period of time, at least 10 years or longer, during the normal or near-normal motor activity (silent/prodromal motor period) before clinical symptoms are sufficient for diagnosis (manifested period) [41]
The UPR, crucial for innate and adaptive immunity, is activated in this situation, suggesting its role in regulating and maintaining the immune response in vitiligo.42 Another recent study analyzed the role of mitochondrial energy metabolism in melanocytes from vitiligo patients, finding reduced ATP production, increased proton leakage, altered expression of glycolytic enzymes, and hyperactivity of the PGC1 axis
Regarding inhibitory neurotransmission, researchers have identified atypical SNPs in genes associated with glutamate decarboxylase (GAD) and atypical copy number variations affecting GABA A receptor-associated genetic sites [11, 12]
In this study, the investigators have hypothesized that the intake of antioxidant vitamins would augment the beneficial effects of exercise in patients with type 2 diabetes
redrag Sikiri, Sven Seiwerth, eljko Grabarevi, Rudolf Ruman, Marijan Petek, Vjekoslav Jagi, Branko Turkovi, Ivo Rotkvi, Stjepan Mie, Ivan Zorii, Pako Konjevoda, Darko Perovi, Ljubica Jurina, Jadranka eparovi, Miro Hanevaki, Branka Artukovi, Mirna Bratuli, Marina Tiljar, Miro Gjurain, Pavao Mikli, Dinko Stani-Rokotov, Zoran Slobodnjak, Nikola Jelovac, Anton Marovi, The influence of a novel pentadecapeptide, BPC 157, on NG-nitro-l-arginine methylester and l-arginine effects on stomach mucosa integrity and blood pressure, European Journal of Pharmacology, Volume 332, Issue 1, 1997, Pages 23-33, ISSN 0014-2999, Seiwerth S, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, Drmic D, Stupnisek M, Misic M, Vuletic LB, Pavlov KH, Barisic I, Kokot A, Japjec M, Blagaic AB, Tvrdeic A, Rokotov DS, Vrcic H, Staresinic M, Sebecic B, Sikiric P
