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or 4) use of a peptide bond isostere in place of the 1-2 peptide bond

Consistent with our historical methodology for adjusting the capital standard Federal rate to ensure that the effects of the annual DRG reclassification and the recalibration of DRG weights are budget neutral under 412.308(c)(4)(ii), we finalized to apply an additional budget neutrality factor to the capital standard Federal rate so that the 10-percent cap on decreases in an MS-DRG's relative weight is implemented in a budget neutral manner (87 FR 49436)

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Vitamin B The majority of Vitamin B vitamins turn food into energy and support healthy cell creation, growth, and development