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While small changes in the scores of these scales might be statistically significant in trials, the impact of such in patients symptoms and quality of life can be meaningless, being important to thoroughly define which score changes are, in fact, impactful [249]

"Just non-stop breathing of all those toxic gases." By Jan.16, a group of healthcare practitioners organized by two non-profits in Northern California arrived to help, offering breathing treatments to first responders at the Eaton Fire basecamp

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For example, during excitotoxicity, the intracellular Ca 2+ concentration is abnormally elevated, leading to an excessive release of glutamate and a massive influx of Ca 2+ into the postsynaptic neuron, triggering an imbalance in Ca 2+ homeostasis and resulting in intracellular Ca 2+ overload