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[75] Various organizations, [90] including the International Union Against Tuberculosis and Lung Disease, the American Academy of Pediatrics, the American Cancer Society, the Centers for Disease Control and Prevention, and the US Food and Drug Administration (US FDA), have expressed concern that e-cigarette use could increase the prevalence of nicotine addiction in youth

Importantly, although individual mutations and their associated GOF effects can result in variable therapeutic vulnerabilities, the restoration of WT p53 function exerts comparable effects across tumours with different mutant p53 in lung cancer mouse models that can be switched from mutant p53 to WT p53 [217]

Smoking cessation programs can help ex-smokers, too

Public Health 2012 , 961724 (2012)

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