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Combined use demonstrates improved outcomes in animal research, including: Faster formation of granulation tissue and wound closure Reduced edema and inflammation Enhanced tendon-to-bone integration and ligament tensile strength Systemic protection of organs such as liver and kidney in ischemia-reperfusion models Systematic reviews of over 35 preclinical studies consistently report positive histological and functional results, with no observed toxicity

Am J Pathol 107(1):5969 Hackett RL, Shevock PN, Khan SR (1995) Alterations in MDCK and LLC-PK1 cells exposed to oxalate and calcium oxalate monohydrate crystals