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In a double-blind study with a placebo group, chronic insomniac patients administered with a DSIP analogue experienced a reduction in sleep latency by an average of 22 minutes, suggesting its potential as a therapeutic agent for severe chronic insomnia patients (Anderer & Saletu, 1991)

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Moreover, nonneutralizing binding antibodies to S2 have been linked to vaccine-mediated protection in a murine model using an alphavirus vectored pan-sarbecovirus [72]

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LL-37 is a broad-spectrum antimicrobial peptide that also reduces inflammation and supports tissue healing, especially in the lungs, skin and GI tract