Both are FDA-approved for type 2 diabetes and chronic weight management when clinical criteria are met
Deep structural changes, significant volume loss, and profound sun damage may need other interventions
For example, a meta-analysis found that two copies of the MTHFR C677T variant (A/A, homozygous) increase the relative risk of heart disease by 38%.[ref][ref] However, not all studies agree, and a large prospective study (n=6,000) found that older people with two copies of the C677T allele were at a 30% decreased risk of death from cardiovascular disease when other parameters were included.[ref] The increased risk is not just due to high homocysteine
Cerebrolysin represents a systems approach many active components, many targets, clinically validated but mechanistically complex
Other orthobiologics such as stem cell therapy or PRP, even newly developed cell editing drugs like Invossa for knee osteoarthritis have robust safety data in humans and ongoing randomized controlled trials to determine their efficacy