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Specifically, 24 studies used conventional regression models (pooled AUC 0.80 [95% CI 0.77-0.82]), while 13 used machine learning models (0.86 [0.81-0.90])

C domains are most commonly encoded in the same coding DNA sequence (CDS) as their acceptor molecules, upstream of the corresponding A domain and there are only very few examples were a C domain is located in the C terminal proximitiy of the preceding CDS in NRPS 32,33,34

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Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review