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Check vitamin B12 levels in people treated with metformin who have symptoms suggestive of vitamin B12 deficiency This will also include patients found to have megaloblastic anaemia (raised mean corpuscular volume [MVC]), who may be asymptomatic (MHRA, 2022)

This helps us make any needed changes

It is important to note that the lipolytic activity characterized in early rodent and cell-based models has not been consistently reproduced in controlled human study

This is a highly invasive solution reserved for when the joint is so severely damaged that nothing else has worked

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