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Vitamin B12 is a water-soluble nutrient, which means it has an exceptionally high safety profile

Oral Supplementation Oral B12 supplements are widely available, but their effectiveness varies

Injections are particularly appropriate for those with: Pernicious anaemia, an autoimmune condition affecting B12 absorption Conditions affecting the stomach or small intestine, such as Crohns disease or coeliac disease Those who have had gastric surgery or bariatric procedures Strict vegans and vegetarians not meeting their B12 needs through food or oral supplements For those who can absorb B12 normally, oral supplements are generally an effective and well-evidenced alternative to injections

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Side effects of B12 shots are rare but can include pain or redness at the site