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Studies conducted on an asymptomatic mouse model of HUA, subjected to acute kidney injury instigated by ischemia-reperfusion (IR-AKI), revealed that sUA could drive macrophage polarization toward the M2 macrophages, thereby expediting the recovery of renal function and structure in IR-AKI (75)

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Academic institutions, independent research organizations, or collaborative pharmaceutical initiatives could theoretically pursue these questions, though competitive dynamics make such studies unlikely in the near term

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