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Moreover, while systemic concerns have been raised, with a study of nicotine pharmacokinetic side effects of ONP use that reported cardiovascular effects of increased heart rate and elevated arterial stiffness indicating potential risks of increased arterial hypertension, atherosclerosis, and myocardial infarction, particularly in individuals with pre-existing cardiovascular conditions (24)

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epilepsy/epileptic fitA chronic neurological and developmental disorder characterized by recurrent, unprovoked seizures, according to the Epilepsy Foundation, which also states that it is the fourth most common neurological disorder