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2016 Jul 1;150(1):164-79

According to the October 4, 1889, edition of the Monroe Daily Independent physicians studying the proliferation of smoking in locations such as San Francisco, California and Denver, Colorado determined that tobacco should be used moderately, if used at all. The four doctors involved in the study concluded that laborers and artisans could smoke all they want without injury, but that brain-workers exposed themselves to the risk of nervous collapse if they indulged in more than one cigarette a day

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