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Moreover, it is demonstrated that intralesional allogeneic ADSCs could decrease the expression of TIMPs and enhance the expression of MMPs, reducing the chances of Peyronies-like plaque ( smooth muscle actin (SMA) of myofibroblasts in tunica albuginea, and inhibit the Rho/RhoA and SMAD signaling pathway ( The effects of intralesional human ADSCs on animal model of PD in acute phase was first assessed in 2013 ( Because of these potential limitations, a single-center, phase I, non-randomized study was conducted to evaluate the efficacy and safety of SC therapy for patients with PD using placental matrixderived mesenchymal SC (PM-MSCs) ( In a word, despite the lack of qualitative trials with larger samples and long-term follow-ups, SC therapy has revealed the advantage of balancing pro-fibrotic and anti-fibrotic elements
