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In the past decade, there has been great interest in the development of BSEs rich in GR, and the primary challenges have been stability and bioavailability, with mixed success

One study showed decreased levels in post-bariatric surgery patients, but this high-risk group had multiple confounding factors

However, no evidence of tumor promotion has been observed in any published Epithalon study, including long-term animal lifespan studies [2]

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More substantial benefits including consistent deep sleep enhancement, comprehensive sleep architecture optimization, and robust recovery improvements typically develop over 1-4 weeks as circadian rhythms stabilize and sleep patterns normalize