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Lipid-based nanoparticles, including solid lipid nanoparticles and nanoemulsions, have demonstrated enhanced protection of SFN from degradation in the gastrointestinal tract, while polymeric nanoparticles such as PLGA-based systems enable sustained release profiles that maintain therapeutic concentrations over extended periods

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As a D-amino acid peptide, FOXO4-DRI is costly to synthesize, and a wrong amino acid at the binding site can sharply cut activity