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Interestingly, the closest relatives of many mtDNA-modifying enzymes, such as mtDNA polymerase, are bacteriophage proteins [94], suggesting that an infection of the mitochondrial ancestor contributed to the development of mtDNA maintenance machinery

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In a healthy intestine, autoimmune and inflammatory reactions are kept under control because SCFAs create a correct balance between Treg cells and Th17 cells

69 Thirdly, during the DPN, excess saturated fatty acids (SFAs) and hyperglycemia depolarize mitochondrial membranes and generate ROS, 70 which eventually produce mitochondrial dysfunction and Schwann cells (SCs) apoptosis

Its unique gastric stability distinguishes it from other regenerative peptides