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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

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qPCR confirmed that the effective downstream cytokines/growth factors (VEGFa, PDGF, FGF, TNF, IGF-1 and BDNF) of these pathways are upregulated by erucamide, but they were dysregulated when we knocked down TMEM19 (Fig

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