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Studies show that QSM-derived iron levels correlate significantly and negatively with cognitive function in AD patients, confirming the role of iron dysregulation in the disease mechanism (179)

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Researchers should validate probe specificity using GSH-depleted controls, such as buthionine sulfoximine (BSO)-treated cells, to confirm that the signal reflects glutathione rather than other intracellular thiols

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Chemotherapy clearance: glutathione may interfere with treatment mechanisms, so active chemotherapy requires explicit oncologist approval first