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some may respond within 15 minutes at higher doses [9] These medications work by enhancing nitric oxide-mediated relaxation of penile smooth muscle, facilitating increased blood flow during sexual stimulation

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Del Buono et al., Tendinopathy and inflammation: some truths, International journal of immunopathology and pharmacology 24, 1 Suppl 2 (2011): 45

doi: 10.1161/HYPERTENSIONAHA.113.01063 69 HermansMMHenryRMDekkerJMNijpelsGHeineRJStehouwerCD